![]() Drugs may interact with MIBG uptake by 5 mechanism: (1) type-1 uptake inhibition (2) inhibition of active transport to vesicles (3) competition in transport to vesicles (4) depletion of neurosecretory vesicle content (5) calcium-mediated mechanism. Papers published demonstrating drugs interfering with MIBG uptake were evaluated. Scientific studies, case report and review articles were collected. The aims of this review paper are: (1) to identify the pharmacological basis of interference of a variety of substances with MIBG uptake and (2) to update the list of drugs that definitely interfere with MIBG on the grounds of evidence in the literature. Thirty years after introduction of the method and over 15 years since the appearance of the first document on pharmacological interference with MIBG, an update on this issue has become necessary. However, scientific literature showed that some drugs are able to or are expected to interfere with MIBG uptake. ( 123) I-metaiodo-benzylguanidine ( MIBG) scintigraphy is considered a valid imaging test to evaluate the cardiac sympathetic nervous system. ![]() Stefanelli, A Treglia, G Bruno, I Rufini, V Giordano, A Pharmacological interference with 123 I-metaiodobenzylguanidine: a limitation to developing cardiac innervation imaging in clinical practice? The preparation of I- 123 mIBG in-house using this technique is recommended.« less Imaging of neuroendocrine tumors in 300 patients following injection of I- 123 mIBG or 1-131 mIBG prepared from a method, the specificity and sensitivity both exceed 90%, correlating well with multiple studies reported in the literature. WR evaluated by MIBG scintigraphy 3 weeks after the onset of STEMI is a significant predictor of MACE in patients with STEMI, independent of LVEF. ![]() ![]() Higher specific activity result in higher uptake of radioiodinated MIBG in all volunteers in the heart (p 45%, WR was a predictor of MACE, pump failure death, cardiac death and progression of heart failure in patients with STEMI. To clarify the effect of specific activity on cardiac uptake of radioiodinated MIBG, the distribution and kinetics of no-carrier-added MIBG (> or = 7.4 TBq/mumol) were compared with those of commercial MIBG (approximately 74 MBq/mumol) in three healthy volunteers by serial imaging and blood sampling. Recent in vivo studies predict enhanced cardiac uptake of this radiopharmaceutical with high specific activity. Radioiodinated meta-iodobenzylguanidine ( MIBG), an analog of norepinephrine, has been used to assess myocardial sympathetic innervation. Effect of specific activity on cardiac uptake of iodine- 123- MIBG.įarahati, J Bier, D Scheubeck, M Lassmann, M Schelper, L F Grelle, I Hanscheid, H Biko, J Graefe, K H Reiners, C ![]()
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